Research and development of enhanced, integrated and accessible flow metering software for industry.

This project was an investigation to find improvements required in the delivery of software for the flow metering industry. The project has resulted in the repackaging of existing software using appropriate technologies. This included developing software that is accessible via the web and extending functionality whereby a user can import and export information in a variety of data formats. The software was successfully revised and is now commercially accessible to the flow metering industry. The project was performed in the context of a KTP (Knowledge Transfer Partnership) programme with academic supervision provided by TUV NEL (the academic partner) on the premises of KELTON® (the commercial partner) who provided day-to-day project management supervision. The project was in collaboration between the two organisations with the joint aims of facilitating knowledge transfer between the organisations and enhancing the market performance of the commercial partner. The main objective of the study was to gain a full understanding of the needs of the flow metering industry in terms of software and delivery via web or standalone application. Web based applications are new to KELTON® so it was necessary to investigate the methods of delivery. The work concentrated on investigating techniques to modularise code, allowing flexible access to data between applications and on data presentation. iv At an early stage of the project an online market survey program was developed and appropriate questions were used to get customer feedback. The results were analysed and used to prioritise work. Following the review, the current software architecture was found to be unsuitable so new approaches were investigated. The software was created using an n-tier architecture which is a method of splitting common code into separate components. Web based applications were found to be slower than standalone applications. However, web applications benefited from not having to fully install software on individual user PCs therefore allowing access from anywhere that users have access to the network

The Impact of Computer-Assisted Sight Word Instruction on the Reading Skills of Students with Significant Intellectual Disabilities

There is a paucity of research identifying instructional methods that promote the reading development of students with significant intellectual disabilities (ID). This research study employed a single subject, multiple baseline design to evaluate the effects of computer-assisted sight word instruction employing constant time delay (CTD) procedures with incidental phonics and comprehension stimuli on the reading skill development of six elementary students with moderate ID and expressive language impairments. Study results suggest that the seven week PowerPoint slide show sight word intervention had very small to moderate intervention effects on receptive sight word identification. However, students learned some incidental letter-sound correspondences and demonstrated gains in sight word comprehension. Study results suggest that the computer-assisted sight word intervention may provide a means to foster the development of foundational reading skills with students with moderate ID. Future research is needed to determine if students generalize the essential reading skills acquired through the computer-assisted intervention to the reading material they encounter in home, school, and community environments

Cwbr Author Interview: Compelling Images Enhance Narrative Histories: Interview With William C. Davis

William C. Davis is the author or editor of more than 40 books on the Civil War and Southern history, as well as numerous documentary screenplays. He has served as historical consultant on various television and film productions. Davis has twice been nominated for the Pulitzer Prize in history and is currently professor of history at the Virginia Polytechnic Institute and State University. His most recent book, The Civil War in Photographs (Carlton 2002), served as the platform for this interview..

Going Viral During a Pandemic: Civil Society and Social Media in Kazakhstan

The covid-19 pandemic forged a more intensely digital world, complicating civil society actors’ menu of options for channeling and framing their advocacy goals. As both a product and study of pandemic-era politics, this dissertation is concerned with understanding how the internet and social media shape associational life in Kazakhstan. I draw on three forms of ethnographic data collected online between October 2020 and February 2022, including semi-structured interviews, visual analysis of social media posts, and digital participant observation. I demonstrate how Kazakhstani civil society actors devise strategies to pursue reform, how they debate theories of political change, and how they exercise agency in a political system that seeks to control the public sphere. I argue that civil society groups use social media platforms to leverage power differentials across levels of administration to advance rights claims and negotiate for reform. Activists and rights defenders flock to various social media platforms because of each site’s unique technological infrastructure. They leverage different logics of visibility and bridge physical and digital forms of contentious politics to demand accountability from an authoritarian government. In addition to providing a more complete understanding of civil society dynamics in Kazakhstan, this study suggests that, in repressive contexts, civil society actors who opt for within-system engagement have not necessarily been coopted and activists do not always take dissent underground. This dissertation is an example of digital political ethnography, which stands to grow not only as a standalone method, but also a bridge to big data analysis in political science. I demonstrate the importance of an ethnographic sensibility while approaching the internet as a site of inquiry to understand political subjectivity

Instructional Methods that Foster the Reading Development of Students with Significant Intellectual Disabilities

Educational legislation has made reading a priority for students with significant intellectual disabilities (ID) and associated speech, language, sensory, or physical impairments. Historically, reading instruction for students with significant ID has focused on sight word instruction, with limited exposure to other essential reading skills. This article focuses on the evidence-based instructional methods that effectively and efficiently foster the reading development of students with significant ID. The authors reviewed the literature from the past 20 years on reading interventions for students with significant ID. In spite of access and opportunity barriers that have inhibited the reading development of students with significant ID, a synthesis of the empirical research on reading instruction suggests that students with significant ID and associated disabilities can learn phonemic awareness, phonics, vocabulary, fluency, and comprehension skills with direct instruction. Implications for providing reading instruction that effectively promotes reading development are discussed and areas for future research are identified

Myosin-Vb functions as a dynamic tether for peripheral endocytic compartments during transferrin trafficking

<p>Abstract</p> <p>Background</p> <p>Myosin-Vb has been shown to be involved in the recycling of diverse proteins in multiple cell types. Studies on transferrin trafficking in HeLa cells using a dominant-negative myosin-Vb tail fragment suggested that myosin-Vb was required for recycling from perinuclear compartments to the plasma membrane. However, chemical-genetic, dominant-negative experiments, in which myosin-Vb was specifically induced to bind to actin, suggested that the initial hypothesis was incorrect both in its site and mode of myosin-Vb action. Instead, the chemical-genetic data suggested that myosin-Vb functions in the actin-rich periphery as a dynamic tether on peripheral endosomes, retarding transferrin transport to perinuclear compartments.</p> <p>Results</p> <p>In this study, we employed both approaches, with the addition of overexpression of full-length wild-type myosin-Vb and switching the order of myosin-Vb inhibition and transferrin loading, to distinguish between these hypotheses. Overexpression of full-length myosin-Vb produced large peripheral endosomes. Chemical-genetic inhibition of myosin-Vb after loading with transferrin did not prevent movement of transferrin from perinuclear compartments; however, virtually all myosin-Vb-decorated particles, including those moving on microtubules, were halted by the inhibition. Overexpression of the myosin-Vb tail caused a less-peripheral distribution of early endosome antigen-1 (EEA1).</p> <p>Conclusion</p> <p>All results favored the peripheral dynamic tethering hypothesis.</p

Network analysis of host-virus communities in bats and rodents reveals determinants of cross-species transmission.

Bats are natural reservoirs of several important emerging viruses. Cross-species transmission appears to be quite common among bats, which may contribute to their unique reservoir potential. Therefore, understanding the importance of bats as reservoirs requires examining them in a community context rather than concentrating on individual species. Here, we use a network approach to identify ecological and biological correlates of cross-species virus transmission in bats and rodents, another important host group. We show that given our current knowledge the bat viral sharing network is more connected than the rodent network, suggesting viruses may pass more easily between bat species. We identify host traits associated with important reservoir species: gregarious bats are more likely to share more viruses and bats which migrate regionally are important for spreading viruses through the network. We identify multiple communities of viral sharing within bats and rodents and highlight potential species traits that can help guide studies of novel pathogen emergence.This work was supported by the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate (US Department of Homeland Security) and the Fogarty International Center (National Institutes of Health). D.T.S.H. acknowledges funding from a David H. Smith post-doctoral fellowship. A.A.C. is partially funded by a Royal Society Wolfson Research Merit award, and J.L.N.W. is supported by the Alborada Trust. Thanks to Paul Cryan and Michael O'Donnell of the USGS Fort Collins Science Center for help with species distribution analyses.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/ele.1249

AXTAR: Mission Design Concept

The Advanced X-ray Timing Array (AXTAR) is a mission concept for X-ray timing of compact objects that combines very large collecting area, broadband spectral coverage, high time resolution, highly flexible scheduling, and an ability to respond promptly to time-critical targets of opportunity. It is optimized for submillisecond timing of bright Galactic X-ray sources in order to study phenomena at the natural time scales of neutron star surfaces and black hole event horizons, thus probing the physics of ultradense matter, strongly curved spacetimes, and intense magnetic fields. AXTAR's main instrument, the Large Area Timing Array (LATA) is a collimated instrument with 2-50 keV coverage and over 3 square meters effective area. The LATA is made up of an array of supermodules that house 2-mm thick silicon pixel detectors. AXTAR will provide a significant improvement in effective area (a factor of 7 at 4 keV and a factor of 36 at 30 keV) over the RXTE PCA. AXTAR will also carry a sensitive Sky Monitor (SM) that acts as a trigger for pointed observations of X-ray transients in addition to providing high duty cycle monitoring of the X-ray sky. We review the science goals and technical concept for AXTAR and present results from a preliminary mission design study.Comment: 19 pages, 10 figures, to be published in Space Telescopes and Instrumentation 2010: Ultraviolet to Gamma Ray, Proceedings of SPIE Volume 773

Network analysis of host–virus communities in bats and rodents reveals determinants of cross-species transmission

Bats are natural reservoirs of several important emerging viruses. Cross-species transmission appears to be quite common among bats, which may contribute to their unique reservoir potential. Therefore, understanding the importance of bats as reservoirs requires examining them in a community context rather than concentrating on individual species. Here, we use a network approach to identify ecological and biological correlates of cross-species virus transmission in bats and rodents, another important host group. We show that given our current knowledge the bat viral sharing network is more connected than the rodent network, suggesting viruses may pass more easily between bat species. We identify host traits associated with important reservoir species: gregarious bats are more likely to share more viruses and bats which migrate regionally are important for spreading viruses through the network. We identify multiple communities of viral sharing within bats and rodents and highlight potential species traits that can help guide studies of novel pathogen emergence